In advanced renal failure, a person can experience weight gain due to fluid retention. This can sometimes be a sign of decompensation and should be evaluated by a healthcare provider. Diuretics can cause an increase in serum creatinine levels, which may need to be monitored and managed based on the individual's condition and medical history. It is important to consult with a doctor or pharmacist to determine the best course of action for managing any changes in weight or kidney function.
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