Yes, it is possible to mix Dexilant and Zantac. However, it is recommended that this combination remains occasional. If you experience frequent stomach pains despite taking Dexilant regularly, it may indicate that Dexilant is not effective for you or that your condition has changed. If heartburn becomes frequent or if other symptoms arise (such as blood in stool, black stools, fever, persistent vomiting, unexplained weight loss), it would be advisable to consult a doctor. Taking measures such as avoiding fatty, spicy, or acidic foods, chocolate, and mint, reducing caffeine, tobacco, and alcohol consumption, can help prevent stomach problems.