Thank you for your interesting question. It is difficult to predict how each person will respond to an antidepressant. There are a variety of effects, with some people gaining a lot of weight and others not at all. Weight gain can be caused by an increase in appetite for high-fat and high-carbohydrate foods, or a reduction in resting metabolism, which is responsible for over 50% of daily energy expenditure. The brain plays a key role in the feedback control of the energy intake and expenditure system. There are several antidepressants that have minimal effect on weight and libido, such as Bupropion, Desvenlafexine, Duloxétine, and Escitalopram and Fluvoxamine to a lesser extent. Your doctor and pharmacist can discuss which one is best for you to avoid complications, side effects, and maximize beneficial effects, depending on your other medications.