. NSAIDs can cause digestive irritation, such as nausea, heartburn, and reflux, even after one dose. Skin reactions, such as itching and red patches, are rare and occur in less than 1% of people. Voltaren gel, when applied topically to the skin, reduces the risk of certain side effects, but can still cause skin reactions such as redness and itching. When considering taking a medication, it is important to weigh the risks and benefits to ensure that the benefits outweigh the risks. If you have any questions, please do not hesitate to ask.