If you are sleeping well with the melatonin and want to taper off the Seroquel, it would be best to consult with your doctor first. Seroquel is sometimes used for more than just sleep issues, so it's important to ensure that stopping it won't impact any other health conditions you may have. Additionally, it's a good idea to check with your pharmacist to make sure that the melatonin won't interact with any other medications you are taking. Ultimately, it's important to prioritize your health and safety when making decisions about your medication regimen.