When dealing with the interaction between Naproxen and Truvada used in PrEP, it is important to consider that there is a risk of increased toxicity or kidney damage when these two medications are combined. However, based on research, using NSAIDs in small quantities for a short period of time is generally compatible with Truvada, especially in young patients at low risk of dehydration and without underlying kidney issues. It is advisable to consult with the physician who prescribed the PrEP in order to potentially adjust the antiviral medications used to reduce the risk of interaction.