Yes, it can be normal to take both Reactine and Benadryl at the same time in certain circumstances. Benadryl is a first-generation antihistamine that may help with itching symptoms due to its sedative effect, but it only lasts for about 6 hours. Reactine, on the other hand, is a second-generation antihistamine that does not cause drowsiness and lasts for 24 hours. It could be beneficial to take Reactine in the morning and use Benadryl only in the evening (or if you won't be doing any activities requiring alertness). This approach aims to provide continuous relief from allergic reaction symptoms throughout the day.