Can you provide me with the reference found on the internet that mentions that Tylenol Sinus is risky to use in conjunction with Cymbalta? Thank you for this information. In my opinion, it is not discouraged to take Tylenol Sinus solely on the basis that someone is taking Cymbalta. The risk of increased pressure from Cymbalta is rather low. If you are not already suffering from uncontrolled high blood pressure, you can take Tylenol Sinus without any problem. However, it is contraindicated to take a syrup containing DM (dextromethorphan) when taking Cymbalta. This could result in a toxicity that is said to be serotoninergic. Have a good end of the day.