The possible side effects of Depo-Provera include absence of menstruation, breast tenderness, swelling, headaches, changes in appetite, weight gain, and possible depression. These side effects occur in around 1 to 10% of patients. It is important to note that when stopping Depo-Provera, it may take up to 9 to 10 months for fertility to return. Your healthcare provider may suggest trying a progestin-only contraceptive pill like Micronor to see if you tolerate it before considering Depo-Provera.
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