The best remedy for relieving the pain caused by mouth ulcers can vary depending on the individual's situation. For recurring mouth ulcers, addressing the underlying cause, such as certain medical conditions, may be beneficial. In cases of infrequent ulcers, applying products like Orabase™ to isolate the lesion from saliva and irritants, as well as using pain-relieving medications like lidocaine or benzocaine (Orajel™) or Tylenol™ and/or Advil™, can help alleviate the pain. Gargling with saline water may also help some individuals in healing the ulcer faster by drying it out. Ultimately, it is a matter of personal preference and effectiveness in each specific situation.