The duration of effectiveness for a syrup (like Tylenol) and a cream (Polysporin) after opening can vary. Typically, syrups are stable for up to 1 year after opening or until the expiration date specified by the manufacturer, whichever comes first. Similarly, creams in tubes are usually effective for up to 1 year or until the manufacturer's expiration date, whichever is sooner. It is important to store these products in ideal conditions, such as in a cool and dry place, and not in the bathroom or kitchen.
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