it is important that your family pharmacist is informed of the lesions in your mouth in order to determine the urgency of intervention and to communicate with your prescribing doctor to obtain a prescription for a medicated mouthwash. This mouthwash will help you to better tolerate the lesions and to promote their healing. Regarding the nausea, I invite you to specify what dose of the medication you are taking, at what frequency (once a day or once a week) and how the medication is administered (by tablets or injection). If the dose is taken once a week, you could ask your doctor or your family pharmacist what he thinks of dividing the dose into two moments in the day. It is also important to make sure that you have a sufficient dose of folic acid or folinic acid in order to reduce the negative impacts of methotrexate on your body. I invite you to discuss this with your family pharmacist since he alone has your pharmacological record in hand. I hope I have answered your questions well. If the answer I have provided is not suitable for your situation, I remain at your entire disposal. Stéphane Villeneuve, pharmacist