Side effects with Zoloft (sertraline) can occur, but they are usually temporary. Common side effects include dry mouth, nausea, and possibly drowsiness or increased alertness. It is possible to take anti-nausea medication to help with any nausea experienced. It is important to note that the positive effects of the medication may take a few weeks to show, while side effects may occur at the beginning but will not last. Ideally, Zoloft should be taken with a meal to enhance its effectiveness. If you need more information, don't hesitate to reach out to a healthcare professional.