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Can a blood test show if someone is taking antidepressants, and if so, how long does it take to show?

Yes, a blood test can detect the presence of antidepressants in your body. The time it takes to detect them can vary depending on the specific antidepressant you are taking and its elimination profile. For example, for venlafaxine, it can take between 48 and 96 hours for the body to eliminate the entire dose, so the medication can be detected up to 4 days after the last capsule you take.