Both Alesse and Venlafaxine have been associated with potential changes in weight, although the likelihood of weight gain or loss is generally low. Alesse may sometimes affect appetite and cause water retention, while Venlafaxine can lead to a loss of appetite in some individuals. The combination of these two medications does not seem to significantly impact weight. It is recommended to maintain a balanced diet and an active lifestyle for overall health. If you have concerns about your weight and nutrition, it may be helpful to consult a nutritionist for personalized advice and guidance.