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Can I apply triple antibiotic Polysporin on a wound even though I am allergic to Avelox and Septra?

Yes, it should be safe to apply Polysporin triple antibiotic ointment on your wound even if you are allergic to Avelox and Septra. The ingredients in Polysporin are different from those in Avelox and Septra, so it is unlikely to cause a reaction. If you have concerns about your allergies, it is always a good idea to consult an allergist for further evaluation.