Yes, Mezavant can potentially cause stomach spasms even if taken correctly with food. It is recommended to take the medication in the middle of a meal to help minimize this side effect. If you suspect that the medication is causing the spasms, it would be best to consult with a pharmacist who can suggest possible adjustments to the dosage while keeping your doctor informed. Hopefully, this information has been helpful to you. Feel free to ask if you have any other questions.