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Can mirtazapine (Remeron) cause restlessness in the legs? I have taken this medication in the past, but it did not cause that.

Yes, mirtazapine (Remeron) can cause restless legs syndrome. The combination of mirtazapine and zopiclone may increase this side effect. It is possible that you did not experience this side effect in the past when taking only one medication, but now that you are taking both, it has appeared.