Yes, it is possible to develop a tolerance to a medication that you have been taking for a long period of time. Our bodies can change over time and sometimes medications that used to work well may start to cause unwanted side effects. It is important to pay attention to any changes in how you feel when taking a medication and to consult with your doctor if you experience any concerning symptoms. It may be necessary to try stopping the medication to see if the symptoms improve. Additionally, there may be other underlying causes for your symptoms that should be explored with your healthcare provider.