Yes, Fetzima has been proven effective in reducing symptoms of anxiety according to recent studies. It may cause a slight increase in weight due to improved appetite compared to the loss of appetite often associated with anxiety. The medication is less likely to cause weight gain compared to other medications in the same class. Additionally, Fetzima may have a lower incidence of sexual side effects compared to other antidepressants. Some experts are starting to suggest its effectiveness in managing pain, although it is not specifically approved for treating chronic pain by Health Canada. Fetzima differs from other antidepressants like Cipralex and Cymbalta mainly in their mechanisms of action, with Fetzima potentially having slightly fewer side effects.