Yes, Seroquel can cause weight gain as a side effect. This is often dose-dependent, with lower doses generally having less of an effect on weight. Some people may experience an increase in appetite while taking the medication. However, for most individuals, weight gain is more likely due to the drowsiness and fatigue caused by the medication, which can lead to reduced physical activity. In some cases, Seroquel may also lead to elevated blood sugar levels, which can contribute to weight gain. It is important to stay informed about these potential side effects and continue to engage in physical activity to help manage your weight.