Taking Intuniv with foods that are high in lipids can indeed affect the effectiveness of the medication. The absorption of Intuniv is greatly increased when taken with a high-fat meal. Some examples of foods rich in fats include red meats like steaks, chicken thighs, oily fish like sardines and mackerel, avocados, nuts (hazelnuts, flaxseeds, peanuts, almonds), and dishes cooked with oils or butter. It is recommended to take Intuniv on an empty stomach to optimize its effects.