To relieve heartburn in the esophagus during pregnancy, you can try taking medications like Zantac (ranitidine) or Pepcid (famotidine) which can provide relief for 8 to 12 hours. These medications are safe to use during pregnancy and can be taken 1 to 2 times a day as needed. It's also helpful to keep a journal of your diet, activities, and emotions to help identify possible triggers for your symptoms. Be diligent in keeping track of these details as it may take some time to determine the cause of your discomfort. If you have any further questions or concerns, don't hesitate to reach out to a healthcare professional for guidance.