Hormone therapy can be stopped all at once without any problem. However, if you wish to reduce the risk of the symptoms returning, you can gradually reduce the dose of hormones. To do this, you can take 1 less Prometrium pill per week for 2 weeks, then 2 less pills per week for 2 weeks, and so on. You can then skip the Estrogel on those days until you stop taking both drugs. Is my answer clear?