The maximum effect of pregabalin can typically be felt after about a week of taking the medication at an effective dose. The effectiveness of the medication can be fully appreciated after 4 to 6 weeks of consistently taking it at the appropriate dosage. It is common to start pregabalin at a low dose to avoid or minimize any potential side effects, but for most people, doses as low as 25 or 50mg per day may not be sufficient. The recommended effective dose can vary between 75 and 150mg per day, but may be higher for some individuals.