Generally, there is no specific time limit for when you can take another dose of Diflucan One. The medication stays in your body for at least 72 hours, so theoretically you could take another dose after that time. However, it would be unusual for it to be necessary to take another dose so soon. If it has been about 1-2 months since your last dose of Diflucan One, you could consider taking another dose. If it has been less than 2 months since your last dose, it might be best to consult a doctor to discuss possible resistance to the medication. It's important to listen to your body and seek medical advice if needed.