In general, patients tend to get used to the drowsiness caused by pregabalin (Lyrica). However, some people may not develop much tolerance to this side effect. Since you have kidney insufficiency, your kidneys may not eliminate pregabalin (Lyrica) as effectively, leading to more pronounced side effects, especially at the beginning of treatment. If drowsiness is currently bothersome to you, it may be a good idea to wait a bit before increasing the dose to see if the side effect improves. If drowsiness remains significant and affects your daily life, waiting before increasing the dose could be beneficial. Your pharmacist can help adjust your prescription to reduce your side effects.