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"I took too much cough syrup by mistake around 14:30, would it be safe to take a Tylenol cold and sinus for the night around 22h?"

Yes, it is safe to take a Tylenol cold and sinus medication at night if you mistakenly took too much cough syrup earlier in the day. Just make sure to check the ingredients in both medications to avoid doubling up on any particular ingredient. It's important not to exceed the recommended daily dosage of acetaminophen or ibuprofen, so be mindful of that when taking multiple medications.