In general, for asthma, the two pumps do not need to be taken one after the other. Each pump is effective on its own. The orange/red pump (Flovent) is important as it treats inflammation in the lungs and should be taken every day, whether or not you have symptoms. The blue pump (Salbutamol) is optional and is only taken as needed for quick relief of symptoms such as coughing, wheezing, or difficulty breathing. If needed, the two pumps can be taken at the same time, with the Salbutamol being taken 5 minutes before the Flovent. It is recommended to consult with a healthcare provider and consider using a specific asthma action plan to help manage your condition.