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Is it normal to have a upset stomach after taking Tylenol? How can I reduce the side effects?

It is not normal to have a sore stomach after taking Tylenol. If this happens, there are a few things you can try to reduce the side effects. First, try taking the Tylenol with a meal instead of on an empty stomach. If that doesn't help, it may be because the Tylenol pills are too big. In this case, you could try switching to Tylenol pills that are labeled as "Easy to Swallow," which are generally smaller in size.