Yes, it is possible to spread out the dose of amoxicillin throughout the day instead of giving a large dose all at once. This can help ensure that the medication stays in the system for a longer period of time to effectively combat the infection. If the taste of the medication is bothersome, you can try mixing it with certain foods like applesauce, yogurt, or chocolate milk. If changing the flavor is necessary, your pharmacist may be able to help find a solution, such as looking for a different brand or creating a flavored mixture.