Is it true that there is a major interaction between Flexeril and Escitalopram?

Yes, there is a potential major interaction between Flexeril and escitalopram. The two medications can affect your serotonin levels, potentially leading to serotonin syndrome. It is important to use Flexeril for the shortest amount of time possible to reduce this risk. Additionally, there is a potential risk of QT prolongation, which may cause an irregular heartbeat, especially in older patients or those taking multiple medications that have this effect. It is advisable to consult with your pharmacist for more information and to review your medication history.