It depends on the individual's reaction and tolerance to each medication. Generally, Benadryl is more effective for skin issues but can cause drowsiness and has a shorter duration of action. Reactine, on the other hand, lasts for 24 hours and may take a few days to reach optimal effect. A combination of both medications can be used for a short period to control the reaction, but Reactine should be used alone once the issue is stabilized. In more severe cases, a higher dose of Reactine may be necessary. It is important to follow the recommended dosage and consult a healthcare professional if you have any concerns.