If your 2-year-old daughter is still running a fever after starting her antibiotics on Saturday night, it may not be normal. Typically, if the antibiotic is working properly, the fever should subside within 48 to 72 hours. If the fever persists after this time frame, it may indicate that the treatment is ineffective and needs to be changed. It would be best to consult with a healthcare professional for further guidance on the next steps.