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My 3-year-old daughter has had a fever of 39.2 since this morning. It is not going down despite taking Tylenol. Can I also give her Advil?

Yes, if your daughter has congestion or nasal discharge, it may be helpful to use a sinus rinse multiple times a day to provide relief. Remember that the goal is not necessarily to lower the fever, but to make the child comfortable. Fever is a natural defense mechanism of the body. If she seems uncomfortable and has inflammation, especially before bedtime, you can consider using Advil, but there is no added benefit to giving both Tylenol and Advil at home.