My partner has been taking Duloxetine and bupropion for 2 years already, I would like to know if this affects the quality of his sperm (fertility).

Yes, there seems to be a risk of decreased fertility with the medications Duloxetine and bupropion. Studies have shown that bupropion can cause a decrease in sperm concentration and motility, which can affect fertility. However, this decrease appears to be reversible once the medication is discontinued. As for Duloxetine, the effects on sperm quality are less clear, but recent studies have suggested that it may also have an impact on sperm performance. It is essential to consult with a healthcare provider for further information and guidance on this matter.