Yes, it is possible for Zoloft to cause dry mouth as a side effect, which can lead to irritation and a burning sensation on the tongue. This side effect affects about 1 in 6 people who take Zoloft. To relieve this discomfort, it is recommended to increase saliva production. There are different products available, some of which may require a prescription, that can help with dry mouth. Additionally, reducing the dosage of the medication with the guidance of a healthcare professional may also help alleviate this side effect. It is recommended to consult with a pharmacist to explore options for increasing mouth hydration, such as products containing Xylitol that can be found in pharmacies.