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What are the causes of a decrease in platelets in the blood (thrombocytopenia)?

Some common causes of decreased platelets in the blood (thrombocytopenia) include bleeding, liver or spleen disease, pregnancy, infection, medications, natural health products, alcohol, and nutrient deficiencies. Bone marrow diseases can also be a factor. It is important to discuss any abnormal laboratory results with a healthcare professional to determine the underlying cause.