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What can I do to help him when he seems uncomfortable and how can I prevent it?

To help a baby who seems uncomfortable due to constipation, you can try increasing their hydration levels by diluting their milk with water. This can help soften their stools. Additionally, make sure to check with a doctor about the necessity of iron supplements, as these can also cause constipation. Starting at 6 months, over-the-counter laxatives like lax-a-day can be used to help soften stools.