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What can I do to treat an uncomfortable angular cheilitis that persists?

To treat a persistent angular cheilitis, you can apply a generous amount of Vaseline™ on your lips 2 to 3 times a day. Additionally, you can apply hydrocortisone cream 0.5% on the corners of your lips in the morning and at night. Make sure to gently rub the cream so it can penetrate the skin. After 7 days, the issue should be resolved.