What is the difference in effectiveness between quetiapine and trazodone?

There is no direct comparison study between quetiapine and trazodone to determine which is more effective. The two medications have different mechanisms of action and cannot be compared in terms of equivalent doses. The goal of treatment is to improve quality of life while minimizing side effects with the smallest effective dose. Quetiapine may cause significant drowsiness, which is why starting at a low dose is generally recommended. If the drowsiness becomes overwhelming, it is advisable to consult with a healthcare provider to adjust the dosage or explore alternative options.