The prescribed dosage for nifedipine cream for an anal fissure is usually to be applied 2 to 4 times a day, for up to 4 weeks. This cream is typically well-tolerated and can be used while breastfeeding. It is important to address any constipation issues for the healing process to be effective. Taking a fiber supplement like Metamucil can help with constipation when used in conjunction with an emollient like Emolax. Make sure to drink plenty of water when taking Metamucil to prevent worsening constipation. It is unlikely for the body to build up a tolerance to long-term use of an emollient like Emolax.