Can an antidepressant become less effective after several years?

Antidepressants can indeed become less effective over time due to various factors such as changes in brain chemistry or tolerance to the medication. It is important to regularly reassess with your healthcare provider to ensure you are receiving the most effective treatment. Testing genetic markers for drug response is a promising area of research, but it is not yet widely used for prescribing antidepressants. As for long-term use of clonazepam with an antidepressant, it is generally not recommended due to the risk of dependence and other potential side effects. It is always best to consult with your healthcare provider for personalized advice on your medication regimen.