It is not recommended to consume alcohol if you are taking fluoxetine, regardless of the time of day. Alcohol can worsen depressive and anxiety symptoms, even with small amounts. It can also worsen side effects like dizziness, drowsiness, and nausea. Additionally, alcohol can impact the quality of sleep, which may worsen or trigger anxiety or depressive symptoms. People with mood disorders like anxiety or depression are at a higher risk of developing substance use disorders, including alcohol. Alcohol can impair judgment, especially when experiencing anxiety or depressive symptoms. Overall, alcohol consumption is associated with negative impacts on physical, mental, and psychological health.