It is generally not dangerous to use antihistamines regularly and long-term. It is recommended to opt for second-generation antihistamines, such as Claritin, Reactine, or Aerius, instead of first-generation ones like Benadryl. It is possible to develop a tolerance to the medication over time, in which case switching to a different antihistamine may be necessary. It is important to inform your healthcare professionals if you are taking these medications regularly. In addition to medication, you can also reduce allergy symptoms by avoiding touching your face after contact with pets, minimizing carpets in your home, regularly cleaning your living space, and keeping pets out of your bedroom if possible. If you experience swelling in the throat or difficulty breathing, seek immediate medical attention.