It is generally not recommended to mix Venlafaxine with cannabis (CBD or THC) or other drugs, as they can all affect the central nervous system in different ways. Mixing these substances can lead to increased toxicity or depression of the central nervous system, which could result in serious side effects. It is best to avoid mixing these substances with Venlafaxine. If you choose to try using cannabis, it is advised to start with a small amount and only use one substance at a time to monitor any potential adverse reactions.