Yes, it is generally recommended to take Zoloft (sertraline) in the evening with dinner because its absorption can be influenced by food, especially fatty foods. However, if taking it in the morning would be more convenient for you or help with insomnia caused by taking the medication at night, it is okay to switch to taking it with breakfast. It is important to take it at around the same time each day so your doctor can adjust your dosage based on how well the medication is working for you. As for drinking alcohol while taking antidepressants, it is usually best to limit alcohol intake as much as possible because alcohol and antidepressants can have opposing effects on the central nervous system. However, having one glass of wine may not have any adverse effects. It is advisable to try drinking alcohol when you do not have to engage in activities that require alertness, such as driving or working. I hope this information helps answer your questions. Have a good rest of the day!