It is generally recommended to take Zoloft (sertraline) in the evening with dinner because its absorption can be influenced by food, particularly fatty foods. However, if taking it in the morning would be more convenient for you or help with any insomnia caused by taking the medication in the evening, it is okay to switch to taking it at breakfast. It is important to take it around the same time each day so your doctor can adjust your dose based on how effective the medication is. As for alcohol, it is best to limit alcohol consumption while taking antidepressants as they can have opposite effects. Alcohol is a depressant of the central nervous system (CNS), while Zoloft is an antidepressant of the CNS. However, having one glass of wine should not have any adverse effects. It is advisable to try it when you do not need to engage in activities that require alertness, such as driving or working. I hope this information helps answer your questions. Have a good rest of your day!