Yes, you can take Tylenol Cold while taking Reactine. However, it is important to consider other factors such as any other medications you may be taking regularly, known health problems, allergies to medications, and whether you are pregnant or breastfeeding. It is also important to clarify which symptoms you want to address with the Tylenol Cold. If your nasal secretions are clear and liquid, it is likely related to allergies. If you have additional cold symptoms like fever, cough, or unusual fatigue, it may be worth considering a different treatment like Aerius or Claritin. It is also possible to add a cortisone pump for additional relief, which can be obtained over-the-counter from your pharmacist. It is recommended to discuss this option with your pharmacist to determine the best course of action for your situation.