It is generally safe to take antihistamines like Claritin or Aerius while taking Zoloft. However, it is not recommended to take Tylenol Cold or Flu medication as it contains a decongestant that may cause side effects such as tremors, agitation, anxiety, and difficulty sleeping. It is best to opt for nasal hygiene with a saline solution like Hydrasense or Sinus Rinse for relief from cold symptoms. If needed, you can take Tylenol for pain relief and consider using throat lozenges for throat irritation. If you have any further questions or concerns, it is best to consult with a healthcare professional.